Villa have lost their past four Premier League fixtures, with consecutive defeats to Tottenham, Wolves, Arsenal and West Ham.
Dean Smith’s side are only three points off the relegation zone and are in dire need of a victory before the international break.
Meanwhile, Southampton came away from Vicarage Road with all three points last time out, thanks to a 1-0 win against Watford, following on from a home draw against Burnley.
Villa beat Saints 1-0 when the sides last met, at St Mary’s, in January, courtesy of a goal from Ross Barkley.
Ahead of this latest meeting, here’s everything you need to know about how to watch and follow the game…
When does Southampton vs Aston Villa kick off?
The match will kick off at 8pm on Friday, November 5.
Is the game on TV?
Yes, the game will be available to watch to Sky Sports subscribers via the Sky Sports Premier League and Sky Sports Main Event channels.
Live coverage for the match will start at 7pm.
Where can I watch the highlights of the game?
The highlights of the game will be available to watch on the Sky Sports website.
Alternatively, you can watch the game highlights on BBC’s Match of the Day program which will be aired on Saturday, November 6 and will start at 10:25pm.
How else can I follow?
You can follow in-depth coverage of the game from our own Villa correspondent Ashley Preece here at BirminghamLive and on his Twitter account (@PreeceObserver).